Human liver tumors in relation to steroidal usage.
نویسندگان
چکیده
Since 1973 a number of investigators have reported an association between liver neoplasia and steroid usage. Through referral material we have examined the histology of over 250 cases of hepatic neoplasia, most in patients receiving steroid medications. The majority have been benign, predominantly focal nodular hyperplasia (55%) and hepatocellular adenoma (39%). The average age was 31.4 years; 83% had significant steroid exposure with an average duration of 71 months for focal nodular hyperplasia and 79.6 months for hepatocellular adenoma. The type of estrogenic agent was predominantly mestranol; however, during the period mestranol was the most frequently used synthetic steroid. A distinct clinical entity of life threatening hemorrhage from the lesion occurred in 31% of patients with hepatocellular adenoma and 9% of patients with focal nodular hyperplasia. Recurrence of benign tumors has occurred in some patients who continued using steroids and regression has been observed in patients who had incomplete tumor removal but discontinued steroid medication. Medial and intimal vascular changes have been present in a large number of the benign tumors. The relationship of these vascular changes to oncogenesis is unclear, but similar lesions have been described in the peripheral vasculature associated with steroid administration. A number of hepatocellular carcinomas have also been seen. Of significance is the young age of these patients and lack of abnormal histology in adjacent nonneoplastic liver. A striking number of the malignant hepatocellular tumors have been of the uncommon type described as "eosinophilic hepatocellular carcinoma with lamellar fibrosis." The epidemiology of liver lesions within this series is difficult to assess, since the material has been referred from very diverse locations.
منابع مشابه
Automatic Classification of Benign And Malignant Liver Tumors In Ultrasound Images
Introduction: Differentiation of benign and malignant liver tumors is very important for finding appropriate treatment procedure. Human eyes sometime are not able to diagnose the type of liver tumor. Texture analysis is considered as a suitable method to increase the diagnostic power of medical images. In this study texture analysis is employed in order to classification of ben...
متن کاملP128: Relationship of Childhood Brain Tumors and Hair Dye Usage During Pregnancy
Brain tumors, which is one of the destructive forms of human being’s cancers, are the second most common children’s cancers. Brain tumors may have an inherited (small percent), acquired reasons due to environmental factors. Nowadays advances in cosmetic industry have increased our ability in the field of youth and beauty. Hair dye products are such innovations. Recent studies showed...
متن کاملP-44: Infertility and Non-Steroidal Anti- Inflammatory Drug Usage (An Experimental Design)
a:4:{s:10:"Background";s:391:"Unusual effect of celecoxib may be seen in some patients that have used this drug for a long time. Celecoxib is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain which is the main feature of celecoxib. The goal of this survey is to assess the effect of celecoxib on male-reproductive s...
متن کاملAutomated differentiation of benign and malignant liver tumors by Ultrasound Images
Background & Aims: Early detection and reliable differentiation of benign and malignant liver tumors could lead to improved cure rate and costs. Ultrasound image (US) is a convenient medical imaging method for interpreting liver tumors. Visual inspection of ultrasound images sometimes is combined with error and needs biopsy to confirm whether a tumor would be benign or malignant. The aim of thi...
متن کاملبررسی الگوی تجویز داروهای ضدالتهاب استروئیدی و غیر استروئیدی مراجعه کننده به داروخانه 13 آبان شهرستان ساری سال87 دی در بیماران
In the present study, the usage pattern of Anti-inflammatory drugs-steroidal and non-steroidal- in patients referred to 13 Aban Pharmacy in Sari was evaluated. The results show a high rate of anti-inflammatory drug prescriptions, mainly by general practitioners with ibuprofen, diclofenac and mefenamic acid being the most widely used NSAIDs and prednisolone, dexamethasone and betamethasone be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 50 شماره
صفحات -
تاریخ انتشار 1983